Accuracy improvement for identifying translation initiation sites in microbial genomes
نویسندگان
چکیده
منابع مشابه
Accuracy improvement for identifying translation initiation sites in microbial genomes
MOTIVATION At present the computational gene identification methods in microbial genomes have a high prediction accuracy of verified translation termination site (3' end), but a much lower accuracy of the translation initiation site (TIS, 5' end). The latter is important to the analysis and the understanding of the putative protein of a gene and the regulatory machinery of the translation. Impr...
متن کاملPrediction of translation initiation site for microbial genomes with TriTISA
UNLABELLED We report a new and simple method, TriTISA, for accurate prediction of translation initiation site (TIS) of microbial genomes. TriTISA classifies all candidate TISs into three categories based on evolutionary properties, and characterizes them in terms of Markov models. Then, it employs a Bayesian methodology for the selection of true TIS with a non-supervised, iterative procedure. A...
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Correct prediction of the translation initiation site is an important issue in genomic research. In this chapter, an in-depth survey of half a dozen methods for computational recognization of translation initiation sites from mRNA, cDNA, and genomic DNA sequences are given. These methods span two decades of research on this topic, from the perceptron of Stormo et al. in 1982 to the systematic m...
متن کاملImproving the Accuracy of Classifiers for the Prediction of Translation Initiation Sites in Genomic Sequences
The prediction of the Translation Initiation Site (TIS) in a genomic sequence is an important issue in biological research. Although several methods have been proposed to deal with this problem, there is a great potential for the improvement of the accuracy of these methods. Due to various reasons, including noise in the data as well as biological reasons, TIS prediction is still an open proble...
متن کاملA Novel Quality Measure and Correction Procedure for the Annotation of Microbial Translation Initiation Sites
The identification of translation initiation sites (TISs) constitutes an important aspect of sequence-based genome analysis. An erroneous TIS annotation can impair the identification of regulatory elements and N-terminal signal peptides, and also may flaw the determination of descent, for any particular gene. We have formulated a reference-free method to score the TIS annotation quality. The me...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2004
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bth390